1-Piperidinecarboxylic acid, 4-(5-chloro-1H-indazol-3-yl)-, 1,1-dimethylethyl ester
tert-Butyl 4-(5-chloro-1H-indazol-3-yl)piperidine-1-carboxylate
CAS: 1198284-74-0
Molecular Formula: C17H22ClN3O2
1-Piperidinecarboxylic acid, 4-(5-chloro-1H-indazol-3-yl)-, 1,1-dimethylethyl ester - Names and Identifiers
1-Piperidinecarboxylic acid, 4-(5-chloro-1H-indazol-3-yl)-, 1,1-dimethylethyl ester - Physico-chemical Properties
| Molecular Formula | C17H22ClN3O2 |
| Molar Mass | 335.83 |
| Density | 1.260±0.06 g/cm3(Predicted) |
| Boling Point | 493.4±45.0 °C(Predicted) |
| pKa | 12.89±0.40(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD12912623 |
1-Piperidinecarboxylic acid, 4-(5-chloro-1H-indazol-3-yl)-, 1,1-dimethylethyl ester - Introduction
tert-Butyl 4-(5-chroo-1H-indazol-3-yl) piperidine-1-carboxylate is an organic compound. Its chemical formula is C19H26ClN3O2 and its molecular weight is 361.88g/mol. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White crystalline solid
-Melting point: 70-72°C
-Solubility: Soluble in organic solvents such as methanol, dichloromethane and chloroform
Use:
-Chemical reagent: can be used as a reagent in organic synthesis
-Drug research: The compound has potential biological activity in the field of drug research and can be used to study the synthesis and properties of new drugs
Preparation Method:
The preparation of this compound usually involves the following steps:
1.4-piperidinecarboxylic acid tert-butyl ester and stannous chloride methyl ruthenium treatment.
2. A condensation reagent of substituted piperidine is added and heated to react.
3. adding aluminum chloride and other reagents, chlorination reaction, generate the target product.
4. After the crystallization purification step, a white crystalline solid product was obtained.
Safety Information:
-This compound may be harmful to the human body and may cause irritation to the respiratory system, skin and eyes. When handling, wear protective gloves, safety glasses and protective face mask.
-Avoid inhaling the dust or gas of the compound and use it in a well-ventilated place.
-Try to avoid direct contact with skin and eyes. If discomfort occurs after contact, rinse with plenty of water immediately and seek medical help.
-The compound should be kept away from ignition and oxidizing agents, stored properly, and avoid mixing with other chemicals.
Nature:
-Appearance: White crystalline solid
-Melting point: 70-72°C
-Solubility: Soluble in organic solvents such as methanol, dichloromethane and chloroform
Use:
-Chemical reagent: can be used as a reagent in organic synthesis
-Drug research: The compound has potential biological activity in the field of drug research and can be used to study the synthesis and properties of new drugs
Preparation Method:
The preparation of this compound usually involves the following steps:
1.4-piperidinecarboxylic acid tert-butyl ester and stannous chloride methyl ruthenium treatment.
2. A condensation reagent of substituted piperidine is added and heated to react.
3. adding aluminum chloride and other reagents, chlorination reaction, generate the target product.
4. After the crystallization purification step, a white crystalline solid product was obtained.
Safety Information:
-This compound may be harmful to the human body and may cause irritation to the respiratory system, skin and eyes. When handling, wear protective gloves, safety glasses and protective face mask.
-Avoid inhaling the dust or gas of the compound and use it in a well-ventilated place.
-Try to avoid direct contact with skin and eyes. If discomfort occurs after contact, rinse with plenty of water immediately and seek medical help.
-The compound should be kept away from ignition and oxidizing agents, stored properly, and avoid mixing with other chemicals.
Last Update：2024-04-09 15:18:08
